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Do you want to matter? 10/21/2017 6:05:01 PM October 21, 2017 (Click for more...) Formulation of 3D Printed Tablet for Rapid Drug Release by Fused Deposition Modeling (FDM): Screening Polymers for Drug Release, Drug-Polymer Miscibility and Printability 10/21/2017 6:05:01 PM October 21, 2017 The primary aim of this study was to identify pharmaceutically acceptable amorphous polymers for producing 3D printed tablets of a model drug, haloperidol, for rapid release by fused deposition modeling (FDM). Filaments for 3D printing were prepared by hot melt extrusion at 150°C with 10 and 20% w/w of haloperidol using Kollidon® VA64, Kollicoat® IR, Affinsiol™15 cP and HPMCAS either individually or as binary blends (Kollidon® VA64+Affinisol™15 cP, 1:1; Kollidon® VA64+HPMCAS, 1:1). (Click for more...) What are Pharmacists Recommending for Infant Teething? 10/21/2017 6:05:01 PM October 21, 2017 In 2011, the Food and Drug Administration issued a warning to avoid use of any benzocaine-containing products for infant teething treatment due to risk of methemoglobinemia. Several benzocaine-containing products, targeted for infant teething, are currently available over-the-counter. Pharmacists are commonly asked for medical advice in the community and there is no current literature evaluating what pharmacists are recommending for infant teething. (Click for more...) Ohio upgrading its drug tracking database system 10/20/2017 9:00:01 AM October 20, 2017 The Ohio Board of Pharmacy reports the state is updating its prescription drug monitoring system. Launched in 2006, the Ohio Automated Rx Reporting System (OARRS) monitors controlled substances prescribed by physicians, dispensed by pharmacies, and taken by patients. The next generation of the system will assess a patient's risk for addiction or overdose, provide red flag alerts on possible safety issues, and offer real-time messaging between health care providers. (Click for more...) Imprimis Pharma to take on Allergan's cyclosporine with cheaper product 10/20/2017 9:00:01 AM October 20, 2017 Imprimis Pharmaceuticals announced Thursday it plans to introduce a less expensive alternative to cyclosporine (Restasis—Allergan). According to Imprimis CEO Mark Baum, the therapy will cost $0.99 for a 1-month supply, with refills starting at $79 a month. Allergan recently sparked controversy after making a deal with the Saint Regis Mohawk tribe that would protect certain patents on Restasis. Earlier this week, however, a U.S. judge invalidated the patents. (Click for more...) Association of antidepressants with incident type 2 diabetes among Medicaid-insured youths 10/20/2017 9:00:01 AM October 20, 2017 A retrospective cohort study focused on the relationship between antidepressant use in minors and risk for type 2 diabetes—a pattern already detected among adults. The investigation focused on Medicaid claims data for 119,608 patients aged 5–20 years who began antidepressant therapy during the time period covering January 1, 2005–December 31, 2009. Colleagues from the University of Maryland, Baltimore and Johns Hopkins Medical Institutions employed discrete-time failure models to assess incident type 2 diabetes, after adjusting for disease risk score based on dozens of covariates. (Click for more...) CDC: Control not achieve in more than half of U.S. adults with hypertension 10/20/2017 9:00:01 AM October 20, 2017 An update from CDC's National Center for Health Statistics reveals that only 48.3% of American adults with hypertension are effectively managing the disease. Based on internal survey data, the authors noted that high blood pressure affected 29% of the U.S. adult population during 2015–16. Hypertension was most likely to be controlled among people aged 40–59 years, at a rate of 50.8%. By comparison, only 49.4% of patients aged 60 years and older and 32.5% of patients aged 18–39 achieved control. (Click for more...) CDC reports rising rates of drug overdose deaths in rural areas 10/20/2017 9:00:01 AM October 20, 2017 Rates of drug overdose deaths in rural parts of the United States have surpassed those in urban areas, according to a new CDC report. In 2015, the most recent year in the study, the rural drug overdose death rate was 17.0 per 100,000, slightly higher than the rate of 16.2 per 100,000 in urban areas. Approximately 52,000 Americans died from drug overdoses in 2015. "The drug overdose death rate in rural areas is higher than in urban areas," said CDC Director Brenda Fitzgerald, MD. (Click for more...) State offering money for technology proposals to fight opioids 10/20/2017 9:00:01 AM October 20, 2017 Ohio is offering money to attract ideas to help stop the opioid crisis that claimed 4,050 lives in the state last year. The Ohio Opioid Technology Challenge, initiated by Gov. John Kasich, is open to anyone, from a medical expert to a concerned citizen. Proposals are due by December 15 and must identify technology that holds the promise of treating pain without opioids and diagnosing, treating, and preventing abuse and overdoses. (Click for more...) Opioid prescriptions decline in Mass. as database is widely used 10/20/2017 9:00:01 AM October 20, 2017 Since the Massachusetts Prescription Awareness Tool (MassPAT) was fully launched a year ago, 97% of health care providers that prescribe narcotics have registered with the database, according to the state Department of Public Health. State officials say the tool has helped contribute to a decline in opioid prescriptions over the last several years. There have been more than 6.5 million searches on MassPAT, with a weekly average of about 125,000 searches. (Click for more...) FDA chief: Menthol, tobacco flavors could do 'both harm and good' 10/20/2017 9:00:01 AM October 20, 2017 FDA Commissioner Scott Gottlieb, MD, said Thursday that the use of flavors in different tobacco products could potentially do "both harm and good." FDA will examine both possibilities as it considers prohibiting flavors such as menthol in cigarettes and e-cigarettes, he said. FDA said 4 years ago that menthol cigarettes were more difficult to quit and likely posed a higher health risk than regular cigarettes—findings the tobacco industry has rejected. Since then, the agency has been considering regulatory action on menthol sales but has remained quiet on the issue for the last few years. (Click for more...) Congresswoman demands investigation into law that stymied DEA on opioid enforcement 10/20/2017 9:00:01 AM October 20, 2017 Rep. Judy Chu (D-CA) is calling for a congressional probe into a 2016 law that undermined DEA's ability to block suspicious shipments of opioids. Her action comes on the heels of recent media reports criticizing the Ensuring Patient Access and Effective Drug Enforcement Act, which actually made it easier for the drugs to reach the black market. (Click for more...) Diplomat acquires 8th Day Software 10/20/2017 9:00:01 AM October 20, 2017 Diplomat Pharmacy has inked a deal to purchase 8th Day Software and Consulting. Financial terms of the transaction were not disclosed. Plans call for 8th Day Software, based in Cordova, TN, to operate under Diplomat subsidiary Envoy Health Management. The specialty pharmacy noted that 8th Day will expand the service offerings of Envoy Health to include IT outsourcing, consulting, and product development. (Click for more...) CVS Pharmacy encourages patients to check their meds on National Check Your Meds Day 10/20/2017 9:00:01 AM October 20, 2017 CVS Pharmacy is encouraging customers to bring in their prescription medications and supplements to their local CVS Pharmacy for free medication reviews on the first annual National Check Your Meds Day. The day, established by Consumer Reports and HHS, will be held on Saturday, October 21st. (Click for more...) Rite Aid's Medicare Advisor tool helps Medicare beneficiaries select prescription drug coverage 10/20/2017 9:00:01 AM October 20, 2017 Rite Aid pharmacies nationwide are providing older adults with free resources to help them select the right prescription drug plan during the annual Medicare Part D enrollment period, or update their existing coverage for 2018. The company's Medicare Advisor comparison tool, available online and in all Rite Aid pharmacies, enables patients and caregivers to request the three lowest-cost prescription drug plans based on current prescriptions filled at the pharmacy. (Click for more...) FDA approves CAR-T cell therapy to treat adults with certain types of large B-cell lymphoma 10/19/2017 9:00:01 AM October 19, 2017 FDA approved on Wednesday axicabtagene ciloleucel (Yescarta—Kite Pharma), a cell-based gene therapy, for the treatment of adults with certain types of large B-cell lymphoma who have not responded to or who have relapsed after at least two other kinds of treatment. The chimeric antigen receptor (CAR) T cell therapy is the second gene therapy approved by FDA. Each dose of axicabtagene ciloleucel is a customized treatment created using a patient's own immune system to help fight the lymphoma. (Click for more...) Dual antithrombotic therapy with dabigatran after PCI in AF 10/19/2017 9:00:01 AM October 19, 2017 In the RE-DUAL PCI study, researchers compared the use of two regimens of dual antithrombotic therapy that included dabigatran with the use of triple antithrombotic therapy that included warfarin among patients with atrial fibrillation who had undergone percutaneous coronary intervention (PCI). (Click for more...) Another outbreak related to the nation's opioid crisis: hepatitis C 10/19/2017 9:00:01 AM October 19, 2017 The opioid epidemic is triggering a flood of public health consequences, including a spike in hepatitis C virus (HCV) infections across the country. The number of new confirmed HCV cases nationwide nearly tripled from 853 in 2010 to 2,436 in 2015, according to CDC, but tens of thousands more are believed to have contracted the disease without knowing it. While most of the 3.5 million Americans who have HCV are Baby Boomers, new carriers tend to be people in their 20s and 30s who use I.V. drugs. (Click for more...) Comparative safety of DOACs and warfarin in VTE 10/19/2017 9:00:01 AM October 19, 2017 Researchers investigated whether direct oral anticoagulants (DOAC) or warfarin was safer to treat venous thromboembolism. The retrospective study analyzed health care data for 59,525 U.S. and Canadian adults who developed the condition between January 1, 2009, and March 31, 2016. Each had been prescribed either warfarin—47,036 patients—or a DOAC—12,489 patients—within 30 days of their initial diagnosis. After mean followup of 85.2 days, 1,029 patients died and 1,967 suffered a major bleeding event. (Click for more...) Anthem joins with CVS to start its own pharmacy business 10/19/2017 9:00:01 AM October 19, 2017 Health insurer Anthem on Wednesday reported that it plans to start its own business to manage prescription drug plans by partnering with CVS Health. The insurer is in the midst of a legal battle with Express Scripts, its current PBM, over claims that Anthem has been overcharged. The insurer said it will start the new business in 2020 after its contract with Express Scripts expires, estimating the savings from the new arrangement to be about $4 billion a year, the bulk of which it said would flow to customers in the form of lower drug costs. (Click for more...) FDA urges clinicians to help limit opioid prescriptions 10/19/2017 9:00:01 AM October 19, 2017 Speaking at a special session of the annual meeting of the National Academy of Medicine, FDA Commissioner Scott Gottlieb, MD, asked health care providers to help the agency find ways to limit both the number of opioid prescriptions and the duration of those prescriptions. "Some limits on duration of use are an inevitability," said Gottlieb. He noted the pharmaceutical industry is supporting limits to duration of use, the supply chain has imposed restrictions, and about 20 states have put limits on first-time opioid prescriptions. (Click for more...) Health Mart highlights community pharmacy tools 10/19/2017 9:00:01 AM October 19, 2017 Health Mart is showcasing its myHealthMart mobile app, DIR Estimator tool, Multi-Store Performance Scorecards, Collaborative Practice Agreement Program, and Physician Outreach Program at the National Community Pharmacists Association Annual Convention. The new tools are designed to help pharmacies improve their clinical, operational, and financial performance. For example, the myHealthMart app enables users to customize key performance metrics, to view store performance, and set goals for each measure. (Click for more...) Study: Formularies offer path to reduce opioid prescribing 10/19/2017 9:00:01 AM October 19, 2017 In a letter published online in the Annals of Internal Medicine, researchers share their analysis of CMS data to examine what role Medicare Part D formularies may have played in restricting opioid prescribing in 2006, 2011, and 2015. The researchers found that in 2006 and 2011, more than two-thirds of drug-dosage combinations had no opioid prescribing restrictions, compared with approximately one-third in 2015. The authors also found that few formularies required step therapy, but prior authorization requirements increased with time. (Click for more...) With rules established, pharmacists can begin prescribing drug that can reverse opiate overdoses 10/19/2017 9:00:01 AM October 19, 2017 A newly implemented law is allowing Wyoming pharmacists to prescribe naloxone to people the practitioner may not have any relationship with. Gov. Matt Mead signed the measure into statute in March and then approved emergency rules written by the state Board of Pharmacy, so pharmacists could start distributing the opioid overdose reversal drug on July 1. According to Mary Walker, executive director of the pharmacy board, the rules—which last 120 days and sought to expedite the implementation of the law—will be replaced with permanent regulations soon. (Click for more...) Maryland congressman joins fight against opioid epidemic 10/19/2017 9:00:01 AM October 19, 2017 Rep. John Delaney (D-MD) is cosponsoring a measure to make it easier for DEA to fight the opioid epidemic. The Opioid Immediate Suspension Order Act of 2017 was introduced by Rep. Gerry Connolly (D-VA) and cosponsored by four Democratic representatives, including Delaney. A 2016 modification to the Controlled Substances Act made it harder for DEA to suspend a drug distributor's license, even if the attorney general saw "an imminent danger to the public health or safety." The new legislation would re-establish the previous threshold for DEA to take action. (Click for more...) Why doctor and hospital groups are fighting a measure to rein in drug costs 10/19/2017 9:00:01 AM October 19, 2017 Several prominent physician and hospital groups are joining pharmaceutical companies to oppose a ballot initiative in Ohio to rein in drug costs paid by state agencies. They warn that drug manufacturers, wholesalers, and pharmacies will actually raise prices on most Ohio residents if the state takes a mandatory discount. The measure, which will appear on the November 7 ballot, is a rehash of an unsuccessful ballot initiative in California to require the state to pay no more for drugs than the discounted rate paid by the federal Veterans Affairs. (Click for more...) Report: Opioids lead in medication-related liability claims 10/19/2017 9:00:01 AM October 19, 2017 Compared with any other drug, opioid analgesics are linked to more medication-related liability claims, according to a new report by Boston-based medical liability insurer Coverys. The company analyzed more than 10,000 closed liability claims from 2012 to 2016 and found that 24% involved opioid analgesics. The next largest category was anticoagulant drugs, at 16%. Of the opioid analgesic-related claims, nearly one-half—46%—involved primary care prescribers. (Click for more...) Two senators strike deal on health subsidies that Trump cut off 10/18/2017 9:00:01 AM October 18, 2017 Two leading senators reached a bipartisan deal on Tuesday to fund critical subsidies to health insurers that President Trump moved just days ago to cut off. The plan by Sens. Lamar Alexander (R-TN) and Patty Murray (D-WA) is an effort to stabilize teetering insurance markets under the Affordable Care Act (ACA). At the White House, virtually as the deal was being announced, Trump voiced support for it while insisting that he would try again to repeal the ACA. The agreement calls for funding the subsidies for 2 years, a step that would provide at least short-term certainty to insurers. (Click for more...) Oral semaglutide vs. placebo and subcutaneous semaglutide for glycemic control in type 2 diabetes 10/18/2017 9:00:01 AM October 18, 2017 A recent Phase II study sought to assess the effect of oral semaglutide on glycemic control in patients with type 2 diabetes. The clinical trial, conducted in 14 countries between December 2013 and December 2014, involved 632 patients with type 2 diabetes and insufficient glycemic control using diet and exercise alone or a stable dose of metformin. Participants were randomized to receive oral semaglutide, subcutaneous semaglutide, or placebo for 26 weeks, with a 5-week followup. (Click for more...) Wisconsin lawmakers push for transparency on prescription drug prices 10/18/2017 9:00:01 AM October 18, 2017 In Wisconsin, three bills introduced by state Rep. Deb Kolste (D-Janesville) call on drug manufacturers and insurance companies to be more transparent about changes in drug pricing and coverage. One of the bills would prevent insurers from suddenly cutting off coverage for a medication, another would require PBMs to register with the state's office of commissioner of insurance before operating in Wisconsin, and the third would require drug manufacturers of name brand and generic prescription drugs to notify the state prior to price increases of more than 25%. (Click for more...) Investigation: The little red drug being pushed on older adults 10/18/2017 9:00:01 AM October 18, 2017 CNN investigators have uncovered an inappropriate prescribing trend in nursing homes involving dextromethorphan hydrobromide–quinidine sulfate (Nuedexta—Avanir Pharmaceuticals). Approved for a rare condition called pseudobulbar affect (PBA), which causes uncontrollable laughing or crying, the drug is carving out a profitable business in the long-term care setting. (Click for more...) CVS Health signs 5-year agreement with Anthem to provide services to support IngenioRx 10/18/2017 9:00:01 AM October 18, 2017 CVS Health has inked a 5-year agreement with Anthem to provide services to support IngenioRx, a new PBM announced by Anthem. Under the agreement, CVS Caremark will manage certain services for IngenioRx, including claims processing and prescription fulfillment. CVS Health's bundled suite of assets, including CVS Pharmacy and MinuteClinic, also enable the company to apply its skill in patient messaging and engagement at the point-of-sale to support IngenioRx. (Click for more...) Cost-effectiveness of testing and treatment for latent TB infection in residents born outside of the United States 10/18/2017 9:00:01 AM October 18, 2017 Researchers evaluated testing and treatment strategies for latent tuberculosis infection (LTBI) in foreign-born residents, an important component in the campaign to achieve U.S. eradication of the disease. Using a simulation model, investigators considered non-native residents with and without HIV infection, end-stage renal disease (ESRD), and diabetes. Based on 10,000 probabilistic simulations, they determined that one strategy or another was almost always cost-effective for these populations. (Click for more...) Minnesota struggles to rein in prescription opioids 10/18/2017 9:00:01 AM October 18, 2017 Although Minnesota has more information than ever before about opioid prescriptions and health officials are responding with a variety of new efforts, the data is still incomplete. The Legislature created a Prescription Monitoring Program in 2007, but only a year's worth of data was retained at any one time in order to protect patient privacy. (Click for more...) Trump drug czar nominee is withdrawing; administration very concerned' about law he championed 10/18/2017 9:00:01 AM October 18, 2017 President Trump announced Tuesday that Rep. Tom Marino (R-PA), his nominee for drug czar, was withdrawing in the wake of an investigative report detailing how he helped pass legislation weakening DEA's to go after drug distributors. The Trump administration's scrutiny of that law has intensified, with Deputy Attorney General Rod Rosenstein saying he is "very concerned about it" and planning to review whether DEA needs "more tools" to carry out its mission. A spokesman for Sen. (Click for more...) Senate committee hears industry testimony on the high cost of drugs 10/18/2017 9:00:01 AM October 18, 2017 The Senate's Health, Education, Labor and Pensions (HELP) Committee on Tuesday heard testimony from pharmaceutical manufacturers and the supply chain in a full committee hearing titled "The Cost of Prescription Drugs: How the Drug Delivery System Affects What Patients Pay." Testifying on behalf of the Pharmaceutical Research and Manufacturers of America, Lori Reilly, the organization’s executive vice president, suggested that drug costs are not, in fact, on the rise. (Click for more...) Generic drug user fees reauthorization: A victory for public health 10/18/2017 9:00:01 AM October 18, 2017 October 1 marked the start of the first reauthorization of the Generic Drug User Fee Amendment (GDUFA). This was a milestone for FDA but also for public health, write Kathleen Uhl, MD, director, Office of Generic Drugs at FDA's Center for Drug Evaluation and Research (CDER), and Michael Kopcha, MD, RPh, director, Office of Pharmaceutical Quality at CDER. "We now have shorter review goals available for applications that are public health priorities," the authors write. (Click for more...) Appeals court tosses $72 million award in talcum powder case 10/18/2017 9:00:01 AM October 18, 2017 An appeals court in Missouri on Tuesday vacated a $72 million award to a woman who had said her long-time use of talcum powder-containing products from Johnson & Johnson contributed to her ovarian cancer. The Missouri Eastern District Court said that Missouri was not the correct location to hear the lawsuit filed by an Alabama woman; the woman died in 2015, just months before her case went to trial in St. Louis Circuit Court. Early last year, a jury awarded her $10 million in actual damages and $62 million in punitive damages. (Click for more...) Dental antibiotics could be adding to C. difficile cases 10/18/2017 9:00:01 AM October 18, 2017 In 2013, dentists reportedly wrote 24 million prescriptions for antibiotics—a known risk factor for Clostridium difficile, which can be fatal. Now, new research out of Michigan appears to confirm a connection between dental antibiotic prescribing and C. difficile cases, which approached 500,000 in 2011. (Click for more...) APhA’s Menighan testifies before Senate on drug pricing 10/17/2017 3:56:39 PM October 17, 2017 APhA Executive Vice President and CEO Thomas E. Menighan, BSPharm, MBA, ScD (Hon), FAPhA, testified in a hearing about drug prices held by the Senate Committee on Health, Education, Labor and Pensions today, driving home the frustration pharmacists often feel when they devote their time to “chasing administrivia” rather than providing care to patients. (Click for more...) Reported penicillin allergy appears to increase the risk of SSIs 10/17/2017 9:00:01 AM October 17, 2017 Massachusetts General Hospital (MGH) researchers have found that surgical patients reported to be allergic to penicillin were much more likely to develop surgical site infections than patients with no documented allergy, due to the alternative antibiotics used to prevent such infections. The research was published in Clinical Infectious Diseases and presented at the IDWeek 2017 conference. The researchers reviewed the medical records of nearly 8,400 patients who underwent common surgical procedures at MGH from 2010 through 2014. (Click for more...) Immunotherapy treatments for cancer gain momentum 10/17/2017 9:00:01 AM October 17, 2017 A new partnership between government researchers and drugmakers is the latest sign that immunotherapy treatment for cancer is advancing rapidly. NIH and the National Cancer Institute (NCI) recently announced a $215 million medical collaboration with 11 medical companies, including AbbVie, Novartis AG, and Johnson & Johnson. Meanwhile, a major lymphoma treatment from Kite Pharma could soon receive approval. (Click for more...) Gestational diabetes and long-term CVD risk 10/17/2017 9:00:01 AM October 17, 2017 Women with a history of gestational diabetes (GD) have a modestly elevated risk for cardiovascular disease (CVD), compared with women who did not have gestational diabetes, according to new research. However, that association could be mitigated by adherence to healthy lifestyle factors, including maintaining a healthful diet, physical activity, nonoverweight/nonobese body weight, and not smoking. For the study, researchers analyzed data from the Nurses' Health Study II, an observational cohort study of U.S. (Click for more...) 7 million American men carry cancer-causing HPV virus 10/17/2017 9:00:01 AM October 17, 2017 Oral human papillomavirus (HPV) infection is common among men, according to new research. The study, published in the Annals of Internal Medicine, found that 11 million U.S. men and 3.2 million U.S. women had oral HPV infections, including 7 million and 1.4 million, respectively, with HPV strains that can cause cancers of the throat, tongue, and other areas of the head and neck. The new study found the risk of infection was elevated for smokers, those with multiple sexual partners, and for MSM. Senior author Ashish A. (Click for more...) Trump declines to express confidence in drug czar nominee 10/17/2017 9:00:01 AM October 17, 2017 Even as President Trump said Monday that he will declare a national emergency next week to address the opioid epidemic, he came under pressure to abandon a nominee for drug czar who championed legislation undercutting the government’s power to go after pharmaceutical companies that contribute to the crisis. Trump declined to express confidence in Rep. (Click for more...) CVS Health, Epic team up to help lower drug costs 10/17/2017 9:00:01 AM October 17, 2017 CVS Health and Epic have partnered on a strategic initiative to help reduce drug costs for patients and improve outcomes by providing prescribers with expanded visibility to lower cost alternatives through enhanced analytics and data sharing. Under the agreement, CVS Health will use Epic's Health Planet population health and analytics platform to generate insights on dispensing patterns and behaviors about medication adherence. (Click for more...) Community pharmacy favorites may be catching the common consumer cold 10/17/2017 9:00:01 AM October 17, 2017 Customers may be starting to shop for OTC drugs with a sharper eye for cost and content, potentially hurting consumer health companies who thought they were insulated from changing tastes. Pfizer said last week that it was "reviewing strategic alternatives" for its non-prescription business, a month after German peer Merck made a similar announcement. Meanwhile, the global leader in non-prescription medicine—a joint venture formed in 2015 by GlaxoSmithKline and Novartis—noted a "marked slowdown" in second-quarter results. (Click for more...) Another record year for U.S. generic drug approvals in 2017 10/17/2017 9:00:01 AM October 17, 2017 FDA's latest fiscal year 2017 activities report reveal that the agency has approved more abbreviated new drug applications (ANDAs) in 2017 than any other year. The 763 approvals (927 approvals and tentative approvals) is 112 more generic approvals than the previous year, 271 more than 2015, and 354 more than in 2014. Meanwhile, the number of complete responses decreased in 2017, from 1,725 in 2016 to 1,603 in 2017. The total number of ANDAs received by FDA also significantly outpaced all prior years as 1,292 were received, which is 439 more than the total ANDAs received last year. (Click for more...) Patents for Allergan's cyclosporine are invalidated 10/17/2017 9:00:01 AM October 17, 2017 United States Circuit Judge William Bryson of the Eastern District of Texas on Monday invalidated four key patents for Allergan's dry-eye treatment cyclosporine (Restasis). Allergan had sought to protect its patents by transferring them to a Native American tribe. The drug manufacturer said that it would appeal the decision. FDA has not yet approved generic versions of the drug. In September, Allergan took the highly unusual step of paying the Saint Regis Mohawk Tribe in upstate New York to take possession of the patents, which then were leased back to the company. (Click for more...) 'Change the conversation' about hormone therapy in menopause 10/17/2017 9:00:01 AM October 17, 2017 Discussions about menopausal hormone therapy over the last 15 years have centered on concerns about elevated risk of breast cancer, heart disease, and dementia. According to North American Menopause Society (NAMS) Executive Director JoAnn Pinkerton, MD, the time has come for clinicians to "change the conversation." Her organization has released a new position statement reassuring the public that hormone therapy is both safe and effective for treating hot flashes, night sweats, and other symptoms that impact quality of life for women in menopause. (Click for more...) Price of cancer drugs rises after launch, unfazed by market 10/17/2017 9:00:01 AM October 17, 2017 A new analysis of injectable oncology drugs demonstrates that prices for the medications generally climb after initial market launch—even if conditions should warrant a drop. The Israeli study examined the cost trajectory of 24 patented products approved from 1996–2012, using average sales prices published by CMS to account for rebates and discounts. After also adjusting for inflation, the investigators determined that the mean cumulative cost increase for the entire group after a follow-up period of 12 years was 36.5%. (Click for more...) Teamsters target drug giant Cardinal Health's response to opioid crisis 10/17/2017 9:00:01 AM October 17, 2017 Cardinal Health is "in the midst of a corporate crisis" over its role in the opioid analgesic epidemic, according to the Teamsters union, which is urging shareholders of Cardinal Health to relieve Cardinal Health CEO George Barrett of his duties as board chairman. The Teamsters accuse Barrett of inadequate leadership while the company faces investigations and multiple lawsuits. The union called on investors to vote to appoint an independent board chairman at Cardinal Health's annual shareholder meeting in November. (Click for more...) Medicare open enrollment begins on October 15, ends December 7 10/17/2017 8:15:21 AM October 17, 2017 It’s that time of year again! In September, CMS announced that the average basic premium for a Medicare prescription drug plan in 2018 is projected to decline to an estimated $33.50 per month. This represents a decrease of approximately $1.20 below the average basic premium of $34.70 in 2017. The Medicare prescription drug plan average basic premium is projected to decline for the first time since 2012. CMS addressed a number of key issues raised by pharmacists in the annual Call Letter: (Click for more...) Effect of application score strategy on interviews offered to PGY-1 pharmacy residency applicants 10/16/2017 6:05:01 PM October 16, 2017 Residency programs may need to spend a large amount of time on the application review process to invite the best candidates for interviews. By using a different scoring strategy, this process could be made more efficient, while still resulting in selection of the most appropriate candidates to interview. The objective of this study was to explore hypothetical scoring strategies for past residency applicants and to determine the percentage of these applicants that would have received an interview offer compared to the program’s standard scoring strategy. (Click for more...) Mediterranean diet, alkaline water may be as effective as PPIs for laryngopharyngeal reflux 10/16/2017 4:15:10 PM October 16, 2017 Treatment of laryngopharyngeal reflux (LPR) with alkaline water and the Mediterranean diet may be as effective as treatment with proton-pump inhibitors (PPIs), according to research published online in JAMA Otolaryngology–Head & Neck Surgery in September. (Click for more...) PTCB names SSgt Mary Johnson CPhT of the Year 10/16/2017 3:59:12 PM October 16, 2017 The Pharmacy Technician Certification Board (PTCB) yesterday recognized Staff Sergeant Mary Johnson as the Certified Pharmacy Technician (CPhT) of the Year. She is the noncommissioned officer in charge of pharmacy services at Geilenkirchen NATO Air Base in Germany—the largest technician-led pharmacy in the United States Air Force. It serves over 2,800 military members and dependents. Today is Pharmacy Technician Day. (Click for more...) CHPA launches DXM age-restriction resource for retailers 10/16/2017 9:00:01 AM October 16, 2017 Millions of Americans use OTC medicines containing the cough suppressant dextromethorphan (DXM) to treat their symptoms, but 1 in 30 teens abuse the medicine to get high, according to the 2016 National Institute on Drug Abuse annual Monitoring the Future survey. This has led the Consumer Healthcare Products Association (CHPA) to announce a new initiative to support retailers in states that have adopted laws prohibiting the sale of OTC medicines containing DXM to minors. (Click for more...) House panel directs DEA to reveal pain medication shipments to WV 10/16/2017 9:00:01 AM October 16, 2017 The House Energy and Commerce Committee has directed DEA to turn over data about opioid analgesic shipments to specific areas in West Virginia. The committee wants DEA to reveal the amount of hydrocodone and oxycodone shipped to six areas in the state. The panel has requested the names of the distributors that supplied the drugs and the names of the pharmacies that purchased them. (Click for more...) In early results, shorter treatment for TB proves effective 10/16/2017 9:00:01 AM October 16, 2017 Preliminary findings from a new study suggest that taking the right antibiotics for 9 months may be as effective against drug-resistant tuberculosis (TB) as taking them for 2 years. The study—which includes 424 patients with drug-resistant TB in Ethiopia, Mongolia, South Africa, and Vietnam—found "favorable outcomes" in about 78% of those treated for 9 months. Clinical trials using the 2-year regimen have seen an 81% success rate. In addition, the shorter regimen appeared to work for patients coinfected with HIV. (Click for more...) A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation 10/16/2017 9:00:01 AM October 16, 2017 The IMPACT-AF clinical trial explored whether an educational intervention targeting patients with atrial fibrillation (AF) would improve uptake of oral anticoagulation, which is important for preventing stroke in this population but is underused. The international study randomized 1,184 AF patients at risk of stroke to participate in a multifaceted intervention that included both patient and provider education, with regular monitoring and feedback. Another group of 1,092 participants, meanwhile, received usual care. (Click for more...) Acting Secretary Hargan declares public health emergency in California due to wildfires 10/16/2017 9:00:01 AM October 16, 2017 HHS Acting Secretary Eric D. Hargan has declared a public health emergency in California due to the wildfires that are devastating the state. The declaration, which is effective retroactively to October 8, allows the secretary to issue a waiver under section 1135 of the Social Security Act for the state to enable CMS to take action that gives beneficiaries and their health care providers and suppliers increased flexibility in meeting key health needs. (Click for more...) California declares state of emergency over deadly hepatitis A outbreak 10/16/2017 9:00:01 AM October 16, 2017 Gov. Edmund G. Brown Jr. of California declared on Friday a state of emergency due to a hepatitis outbreak that has taken at least 18 lives. With the declaration, state health officials can buy additional doses of the hepatitis A vaccine to try to stop the outbreak. "We have the capacity to use as much vaccine as we can get our hands on," said Gil Chavez, MD, state epidemiologist with the California Department of Public Health. The outbreak started in San Diego's homeless community in late 2016; but it has since spread to other areas, including Los Angeles and Santa Cruz counties. (Click for more...) Walgreens selects IBM to support field services 10/16/2017 9:00:01 AM October 16, 2017 Walgreens will deploy IBM retail analytics at more than 8,100 locations nationwide to enhance its stores' IT systems. The goal is to improve the efficiency of field service support at these locations, according to IBM. The new agreement will integrate IBM's unique capabilities with hardware and software from different vendors under one roof, which is expected to furnish more efficient operation of technology across each store. IBM Cloud also will be used to determine the level of support that will likely be needed at each Walgreens location based on service request history. (Click for more...) Pharmacists say lower payment rates could push them out of business 10/16/2017 9:00:01 AM October 16, 2017 Pharmacists across Ventura County, CA, warn that payment rates that reduce reimbursements for many Medi-Cal prescriptions could push independent pharmacies out of business. The pharmacists say the lower rates were triggered by changes involving the Gold Coast Health Plan, a publicly funded agency that administers Medi-Cal health insurance to more than 200,000 low-income individuals in Ventura County. A year ago, the commission that governs Gold Coast awarded its contract for managing its medication program to OptumRx, part of the UnitedHealth Group. (Click for more...) Where the FDA is going under Trump 10/16/2017 9:00:01 AM October 16, 2017 FDA Commissioner Scott Gottlieb says part of what his agency does "is issue regulations to try to create a more modern framework for new technologies, new ways of doing business. It isn't a question of regulations or no regulations. I think it is a question for us of smart regulations." He says FDA is committed to the food labeling regulations. "This is an issue of public health," he states. "We have implemented some delays in the implementation of those regulations. (Click for more...) REMS format and content: FDA offers draft guidance 10/16/2017 9:00:01 AM October 16, 2017 On October 11, FDA released updated draft guidance for the format and content of a risk evaluation and mitigation strategy (REMS) document for prescription drugs and biologics. The 34-page draft, which revises 2009 draft guidance, removes information related to REMS assessments and proposed REMS modifications that are being addressed in separate guidance documents. The draft is meant to help ensure REMS documents are clear, understandable, and to the extent possible, consistent in content and format. (Click for more...) Lower license fees for pharmacists, others to cost Missouri $2 million 10/16/2017 9:00:01 AM October 16, 2017 Under new rules from the Missouri Department of Insurance, Financial Institutions, and Professional Registration, thousands of pharmacists, podiatrists, and psychologists in the state will have lower license fees. The rules were filed in stages, with the largest of the proposed changes appearing in the May 1 edition of the Missouri Register. The state Board of Pharmacy first proposed lowering fees for approximately 1,300 pharmacies, 2,600 drug distributors, and 15,405 pharmacy technicians, which amounts to about $1.6 million less in revenue for Missouri. (Click for more...) States sue over Trump-halted ACA payments 10/16/2017 9:00:01 AM October 16, 2017 Eighteen states and Washington, DC, have filed a lawsuit to stop President Trump from halting key Affordable Care Act (ACA) payments to insurers. On October 12, Trump announced he would stop making the payments, which led to an outcry from critics saying he was sabotaging the health care law. The complaint will seek a temporary restraining order, preliminary injunction, and permanent injunction requiring the cost-sharing reduction payments be made. (Click for more...) New Drugs: Betrixaban, Voxilaprevir/sofosbuvir/velpatasvir, and Glecaprevir/pibrentasvir 10/15/2017 6:05:01 PM October 15, 2017 (Click for more...) Medication management in Minnesota schools: The need for school nurse-pharmacist partnerships 10/15/2017 6:05:01 PM October 15, 2017 Pharmacist participation in school medication management (MM) is minimal. School nurses are responsible for increasingly complex medication administration and management in schools. (Click for more...) Poly(amidoamine) (PAMAM) dendrimers as a pharmaceutical excipient. Are we there yet? 10/15/2017 6:05:01 PM October 15, 2017 Drug solubility could affect the therapeutic use of a drug because the biological activity of a drug is only possible if some fraction of a dissolved drug can permeate and overcome biological membranes to reach its site of action. The solubility-permeation interplay is therefore, probably the most important factor in determining a successful therapeutic outcome of any drug because more than 40% of marketed drugs and more than 70% of pipeline drugs show poor water solubility. (Click for more...) Fabrication and Use of PLGA-based Formulations Designed for Modified Release of 5-Fluorouracil 10/15/2017 6:05:01 PM October 15, 2017 5-fluorouracil (5-FU) is a chemotherapeutic agent that has been used for the treatment of a variety of malignancies since its initial introduction to the clinic in 1957.1 Due to its short biological half-life, multiple dosings are generally required to maintain effective 5-FU plasma concentrations throughout the therapeutic period. Clinical studies have shown that continuous 5-FU administration is generally superior to bolus injection as exhibited by lower toxicities and increased therapeutic efficacy. (Click for more...) Effect of Phosphate Ion on the Structure of Lumazine Synthase, an Antigen Presentation System from Bacillus anthracis 10/15/2017 6:05:01 PM October 15, 2017 Lumazine synthase (LS) is an oligomeric enzyme involved in the biosynthesis of riboflavin in microorganisms, fungi and plants. LS has become of significant interest to biomedical science because of its critical biological role and attractive structural properties for antigen presentation in vaccines. LS derived from Bacillus anthracis (BaLS) consists of 60 identical subunits forming an icosahedron. Its crystal structure has been solved, but its dynamic conformational properties have not yet been studied. (Click for more...) In vitro-in vivo correlations of carbamazepine nano-dispersions for application in formulation development 10/15/2017 6:05:01 PM October 15, 2017 During formulation development, efficiently integrating in vitro dissolution testing can significantly improve one’s ability to estimate in vivo performance and aide in the selection of premier drug candidates. The concept of in vitro - in vivo relationship/correlation (IVIVR/IVIVC) has garnered significant attention from pharmaceutical scientists to predict expected bioavailability characteristics for drug substances and products. (Click for more...) Polymorphism, Intermolecular Interactions, and spectroscopic properties in Crystal Structures of Sulfonamides 10/15/2017 6:05:01 PM October 15, 2017 The antibiotics family of sulfonamides has been used worldwide intensively in human therapeutics and farm livestock during decades. Intermolecular interactions of these sulfamides are important to understand their bioactivity and biodegradation. These interactions are also responsible for their supramolecular structures. The intermolecular interactions in the crystal polymorphs of the sulfonamides, sulfamethoxypyridazine and sulfamethoxydiazine, as models of sulfonamides, have been studied by using quantum mechanical calculations. (Click for more...) Professional liability insurance: Should you carry your own policy? 10/15/2017 1:38:54 PM October 15, 2017 A question I frequently get asked from student pharmacists and my fellow New Practitioners alike is “Should I carry my own liability insurance?” In this article, I will highlight areas where professional liability is necessary, and the pros and cons of carrying it. (Click for more...) Trump to end key ACA subsidies, a move that will threaten the law's marketplaces 10/14/2017 9:00:01 AM October 13, 2017 Making good on months of threats, President Trump on October 12 moved to end federal subsidies that help millions of lower-income Americans afford health coverage. The payments to insurers, worth about $7 billion for 2017, are critical to the marketplaces created by Barack Obama's Affordable Care Act (ACA). Terminating them would provide justification for any carrier to backpedal on its federal contract to sell health plans for next year, causing tremendous disruption. (Click for more...) The Use of a GroEL-BLI Biosensor to Rapidly Assess Pre-Aggregate Populations for Antibody Solutions Exhibiting Different Stability Profiles 10/14/2017 12:05:01 AM October 13, 2017 An automated method using biotinylated GroEL-streptavidin biosensors with Bio-Layer Interferometry (GroEL-BLI) was evaluated to detect the formation of transiently formed, pre-aggregate species in various pharmaceutically relevant monoclonal antibody (mAb) samples. The relative aggregation propensity of various IgG1 and IgG4 mAbs was rank-ordered using the GroEL-BLI biosensor method, and the least stable IgG4 mAb was subjected to different stresses including elevated temperatures, acidic pH, and addition of guanidine-HCl. (Click for more...) Glecaprevir and pibrentasvir in patients with HCV and severe renal impairment 10/13/2017 9:00:01 AM October 13, 2017 Treatment is limited for patients trying to manage both hepatitis C (HCV) and severe renal dysfunction, but a novel combination of two drugs offers promise. To assess the safety and efficacy of glecaprevir and pibrentasvir in this population, a multinational team of researchers executed a Phase III trial. They recruited more than 100 patients with HCV and concomitant stage 4 or 5 chronic kidney disease. Combination therapy was administered for a period of 12 weeks on an open-label basis. (Click for more...) FDA panel endorses gene therapy for a form of childhood blindness 10/13/2017 9:00:01 AM October 13, 2017 The emerging field of gene therapy continues to make strides, the latest milestone coming October 12 as an FDA advisory committee recommended approval of its first use for an inherited disorder. Voretigene neparvovec (Luxturna—Spark Therapeutics) was developed to treat RPE65-mutation associated retinal dystrophy, a rare condition characterized by childhood onset of progressive blindness. Clinical study showed rapid and measurable vision improvement in participants, which was sustained after more than 3 years of followup, with no adverse reaction to the gene therapy itself. (Click for more...) NIH partners with biopharma companies to speed development of new cancer immunotherapies for more patients 10/13/2017 9:00:01 AM October 13, 2017 NIH has teamed up with 11 biopharmaceutical companies to launch the Partnership for Accelerating Cancer Therapies (PACT). The 5-year public-private research collaboration, part of the Cancer Moonshot, will focus initially on efforts to identify, develop, and validate robust biomarkers to advance new immunotherapy treatments that harness the immune system to fight cancer. The Foundation for the National Institutes of Health will manage the partnership, with FDA advising. (Click for more...) Older adults with dementia at risk for inappropriate medications 10/13/2017 9:00:01 AM October 13, 2017 Researchers in Europe who studied more than 2,000 older adults with dementia found that 60% had been prescribed at least one potentially inappropriate medication, while over 25% had received at least two such drugs. Residents of long-term care facilities who were at least 80 years old and had dementia were at greater risk of receiving two or more such potentially unsuitable medicines, according to the study published in Age and Ageing. (Click for more...) CVS Health recognizes its 30,000 pharmacists during American Pharmacists Month 10/13/2017 9:00:01 AM October 13, 2017 As part of American Pharmacists Month, CVS Health is honoring its 30,000 pharmacists. Larry J. Merlo, the company's president and CEO, noted: "As our nation's health care landscape changes, our pharmacists are being called upon to play a broader role in a patient's overall health care team. (Click for more...) Medicare offers improved access to high-quality health coverage choices in 2018 10/13/2017 9:00:01 AM October 13, 2017 CMS has issued the Star Ratings for the 2018 Medicare health and drug plans. With the release of the Star Ratings, individuals covered by Medicare will have greater access to high-quality health choices for their Medicare coverage for 2018. "Medicare is committed to empowering seniors to choose high-quality health and drug plans that fit their needs and the needs of their families," said CMS Administrator Seema Verma. "More high-quality choices mean improved quality care and better customer service at lower cost. (Click for more...) FDA: Ban on free tobacco samples includes e-cigs 10/13/2017 9:00:01 AM October 13, 2017 FDA's ban on free samples of tobacco products includes electronic cigarettes, according to guidance finalized by the agency this week. The ban on free samples of tobacco products covers any tobacco product that is subject to FDA regulation, including components of tobacco products such as e-liquids and refillable cartridges for e-cigarettes. While FDA finalized the regulation prohibiting free samples in 2010, the rule then only applied to cigarettes, including roll-your-own tobacco and smokeless tobacco products. (Click for more...) Warren, Murkowski urge Trump to officially declare opioid epidemic a national emergency 10/13/2017 9:00:01 AM October 13, 2017 Sens. Elizabeth Warren (D-MA) and Lisa Murkowski (R-AK) have called on President Trump to officially declare the nation's opioid epidemic a national emergency. In August, the president said the White House was "drawing documents now" to make such a declaration, which would allow access to greater resources and expedite efforts to respond to the opioid crisis. (Click for more...) Local pharmacists see spike in prescription fraud 10/13/2017 9:00:01 AM October 13, 2017 Elizabeth Vieira, a pharmacist at Pleasant Garden Drug Store in Pleasant Garden, NC, is seeing an increase in people trying to use fraudulent prescriptions to purchase drugs. She says in the past 2 months, pharmacists in her store have encountered at least four fake prescriptions. "Nine times out of 10 we know immediately that it's fake," Vieira said. Patients also have attempted to change dates or dosages on real prescriptions. Vieira noted that once pharmacists check with the doctor and find discrepancies, they call the police. (Click for more...) Bartell Drugs enlists LexisNexis-eRx platform to verify prescribers 10/13/2017 9:00:01 AM October 13, 2017 Bartell Drugs has become the first user of LexisNexis VerifyRx, a platform that performs real-time prescription compliance checks within existing pharmacy workflows. The solution was developed by LexisNexis Risk Solutions and eRx Network. LexisNexis Risk Solutions said the solution leverages eRx's real-time pharmacy connectivity and LexisNexis' provider validation service, covering more than 8.5 million providers. (Click for more...) New study finds perception of risks diluted by lengthy adverse effects list 10/13/2017 9:00:01 AM October 13, 2017 How a drug's adverse effects are listed in direct-to-consumer (DTC) marketing influences the public's perceived level of risk from the product, evidence suggests. In a study series and meta-analysis, investigators from the London School of Business compared responses to different pharmaceutical ads that either listed adverse effects in their entirety or that named only the most serious of them. (Click for more...) The solubility-permeability trade-off of progesterone with cyclodextrins under physiological conditions: Experimental observations and computer simulations 10/13/2017 6:05:01 AM October 13, 2017 This study intended to evaluate the effect of cyclodextrins on the apparent solubility and permeability of lipophilic drugs under physiological conditions and establish in silico model to choose the optimal amount of cyclodextrins for cyclodextrin-containing oral formulations. In order to study the effect of cyclodextrins under physiological conditions, bile salts and lecithin were added into the rat intestinal perfusion solution to simulate the fasted intestinal fluid. (Click for more...) Antitumor Efficacy and Toxicity of 5-FU-loaded PLGA Pellets 10/13/2017 6:05:01 AM October 13, 2017 The aim of this study was to formulate a biodegradable implant capable of imparting local anti-tumor activity through the sustained release of the chemotherapeutic agent, 5-fluorouracil (5-FU). Thus injectable pellets ( (Click for more...) Potential of cationic-polymeric nanoparticles for oral delivery of naringenin: In vitro and in vivo investigations 10/13/2017 6:05:01 AM October 13, 2017 To improve the bioavailability and anticancer potential of naringenin (NRG) by developing a drug-loaded polymeric nano-delivery system. NRG-loaded eudragit E100 nanoparticle (NRG-EE100-NPs) system was developed, and physicochemically characterized. In vivo pharmacokinetic and in vitro cytotoxicity ability of the NRG-EE100-NPs was investigated. In vivo anticancer activity was evaluated in murine BALB/c mice-bearing colorectal tumor. The NRG-EE100-NPs had an optimum mean particle size (430.42±5.78nm), polydispersity index (0.283±0.089) with percent entrapment efficiency (68.83±3.45%). (Click for more...) Stable and Fast-Dissolving Amorphous Drug Composites Preparation via Impregnation of Neusilin® UFL2 10/13/2017 6:05:01 AM October 13, 2017 A promising approach to increase the aqueous solubility, hence the bioavailability, of poorly water-soluble drugs is to convert them into their amorphous state through impregnation into mesoporous silica. Unfortunately, mesoporous silica is not yet available in bulk quantities due to high manufacturing costs. In this work, feasibility of using a commercially available cost-effective mesoporous fine grade Neusilin® UFL2 to prepare amorphous drug composites of two model poorly soluble drugs, Fenofibrate and Itraconazole, is established. (Click for more...) Suitability of the AUC ratio as an indicator of the pharmacokinetic advantage in HIPEC 10/13/2017 6:05:01 AM October 13, 2017 The purpose of this study was to evaluate the area under the concentration time curve (AUC) ratio as an optimal indicator of the pharmacokinetic advantage during hyperthermic intraperitoneal perioperative chemotherapy (HIPEC). (Click for more...) Determination of non-spherical morphology of doxorubicin-loaded liposomes by atomic force microscopy 10/13/2017 6:05:01 AM October 13, 2017 The 3-D morphology of doxorubicin (DOX)-loaded liposomes with a size of ca. 100 nm was characterized by AFM in an aqueous environment. Prolate liposomes appear in accordance with linear expansion of DOX fiber bundles precipitated inside liposomes. Oblate and concave liposomes were simultaneously observed with increased DOX concentrations; however, their morphologies were not readily determined by 2-D cryo-TEM imaging. (Click for more...) Community pharmacies support National Check Your Meds Day 10/12/2017 9:00:01 AM October 12, 2017 HHS and the advocacy group Consumer Reports have designated October 21 as National Check Your Meds Day, and community pharmacies such as CVS Health will be participating in the initiative. The idea is for consumers, at least once a year, to take all of their medications to a pharmacist or physician for a "brown bag" review to check for potential harmful drug interactions and possibly eliminate unnecessary drugs. (Click for more...) Epidurals do not prolong labor 10/12/2017 9:00:01 AM October 12, 2017 Contrary to widely held belief, researchers in China have demonstrated that epidural anesthesia administered in the final stage of delivery does not prolong the duration of labor. The evidence comes from a double-blinded trial of 400 laboring patients, each randomly assigned to receive epidural anesthesia or a saline solution. Average time from full cervical dilation to delivery was comparable between the two groups of women, as were the number of forceps deliveries, cesarean sections, and episiotomies. (Click for more...) Ibuprofen better than morphine for kids after minor surgery 10/12/2017 9:00:01 AM October 12, 2017 The Canadian Medical Association Journal has reported new study results indicating that children should be given ibuprofen—not oral morphine—after minor orthopedic surgery. The clinical trial, performed in Ontario, included 154 patients between the ages of 5 and 17 years. While both approaches worked equally well to relieve pain—although neither completed negated it—adverse effects such as drowsiness, dizziness, nausea, vomiting, and constipation occurred more frequently with morphine. (Click for more...) Romosozumab or alendronate for fracture prevention in women with osteoporosis 10/12/2017 9:00:01 AM October 12, 2017 For postmenopausal women with osteoporosis at high risk for fracture, romosozumab treatment for a year followed by alendronate led to significantly lower risk of fracture compared with alendronate alone, according to new research. The Phase III study involved more than 4,000 postmenopausal women with osteoporosis and a fragility fracture. The women were randomly assigned to receive monthly subcutaneous romosozumab (210 mg) or weekly oral alendronate (70 mg) in a blinded fashion for 1 year, followed by open-label alendronate for both groups. (Click for more...) New Jersey seeks to expand opioid prescription monitoring to veterinarians 10/12/2017 9:00:01 AM October 12, 2017 New guidelines in New Jersey aim to prevent human abuse of medications prescribed to pets. The guidelines call on veterinarians who prescribe opioids to use the New Jersey Prescription Monitoring Program. Under the program, physicians must consult with the database when prescribing opioids, and pharmacies must report prescription data that is shared with more than a dozen other states. Veterinarians are not required to check the database but are encouraged to participate voluntarily. (Click for more...) An old-school pharmacy hand-delivers drugs to Congress 10/12/2017 9:00:01 AM October 12, 2017 As a courtesy to members of Congress, the oldest community pharmacy in the nation's capital shuttles prescription drugs to legislators as well as their families, staffers, and lobbyists. Grubb's, which has been doing business since 1867 and catering to lawmakers for decades, also services the general public. With daily volume of as many as 800 orders, owner Mike Kim employs more than 30 pharmacists, technicians, and support staff—including five drivers. (Click for more...) Pharma's Puerto Rico problems could mean drug shortages: FDA chief 10/12/2017 9:00:01 AM October 12, 2017 FDA Commissioner Scott Gottlieb, MD, says the United States could soon see minor drug shortages due to delays in restoring manufacturing operations in Puerto Rico, which is still recovering from the devastation of Hurricane Maria. Most major drug companies have manufacturing facilities on the island, and 10% of drugs prescribed in the United States are made there. Drugmakers are working to get facilities fully online, but face an unstable power supply and challenges getting materials used in the manufacturing process. Gottlieb predicted U.S. (Click for more...) FDA taking steps to advance patient engagement in the agency's regulatory work 10/12/2017 9:00:01 AM October 12, 2017 FDA on Wednesday hosted the first meeting of the Patient Engagement Advisory Committee, a significant step forward in the agency's efforts to deepen the involvement of patients in its regulatory activities. The advisory committee was founded by FDA's Center for Devices and Radiological Health (CDRH). Involving the patient in identifying health priorities and outcomes desired from health interventions is critically important. (Click for more...) 340B: Health system execs push back on narrowing of drug discount program 10/12/2017 9:00:01 AM October 12, 2017 The House Energy and Commerce's subcommittee on Oversight and Investigations on Wednesday conducted a hearing on the federal 340B drug discount program. Proponents of the program say that the discounts help offset the cost of care for uninsured and low-income patients, while critics warn it can be abused when savings are accrued but not passed on to patients, with many calling for the program to be narrowed or eliminated. (Click for more...) In start to unwinding the health law, Trump to ease insurance rules 10/12/2017 9:00:01 AM October 12, 2017 President Trump is expected to sign on Thursday an executive order that would initiate the unwinding of the Affordable Care Act (ACA). With the order, the president will direct federal agencies to take actions aimed at providing less expensive options and fostering competition in the individual insurance markets. According to two senior White House officials, the specific steps in the order will represent just the first moves in his White House's effort to strike parts of the ACA. (Click for more...) Medicare plans place few restrictions on coverage of prescription opioids, Yale study finds 10/12/2017 9:00:01 AM October 12, 2017 New research from Yale University indicates that Medicare plans have few restrictions on prescription opioid coverage. For the observational study, researchers reviewed prescription drug plan formulary files from CMS in 2006, 2011, and 2015. They included data from Medicare Advantage and Part D plans, looking at coverage for all opioids except methadone. In 2015, one-third of the drugs were prescribed with no restrictions, according to the research. While that figure is down from two-thirds in 2006, the researchers note that a large portion still had no prescribing limitations. (Click for more...) Effects of behavioral interventions on inappropriate antibiotic prescribing in primary care 12 months after stopping interventions 10/12/2017 9:00:01 AM October 12, 2017 Research confirmed that peer comparison and accountable justification—but not suggested alternatives—effectively curtailed inappropriate prescribing of antibiotics for acute respiratory infections (ARIs). However, investigators also wanted to know if these techniques continued to work 1 year after they ended. The study was conducted at 47 primary care practices in Boston and Los Angeles, with participation by nearly 250 clinicians randomly allocated to one, two, or all three interventions—or none at all. (Click for more...) Editorial Advisory Board 10/12/2017 6:05:01 AM November 01, 2017 (Click for more...) New polymorph form of dexamethasone acetate 10/12/2017 12:05:01 AM October 11, 2017 A new monohydrated polymorph of dexamethasone acetate (DEX-II) was crystallized and its crystal structure characterized. The different analytical techniques used for describing its structural and vibrational properties were: single crystal (SCXRD) and polycrystal (PXRD) X-ray diffraction, solid state nuclear magnetic resonance (solid-state NMR), infrared spectroscopy (IR). A Hirshfeld surface (HS) analysis was carried out through self-arrangement cemented by H-bonds observed in this new polymorph. (Click for more...) Understanding Protein-Interface Interactions of a Fusion Protein at Silicone Oil-Water Interface Probed by Sum Frequency Generation Vibrational Spectroscopy 10/12/2017 12:05:01 AM October 11, 2017 Protein adsorbed at the silicone oil-water interface can undergo a conformational change that has the potential to induce protein aggregation upon storage. Characterization of the protein structures at interface is therefore critical for understanding the protein-interface interactions. In this paper, we have applied sum frequency generation (SFG) spectroscopy for studying the secondary structures of a fusion protein at interface and the surfactant effect on protein adsorption to silicone oil-water interface. (Click for more...) Predicting solubility/miscibility in amorphous dispersions: It’s time to move beyond regular solution theories 10/12/2017 12:05:01 AM October 11, 2017 The evolving challenges associated with the development of poorly soluble drug molecules have been met with major advances in drug solubilization. In particular, amorphous solid dispersion technology is becoming an increasingly important option to enhance oral bioavailability by creating prolonged drug supersaturation to maximize the driving force for intestinal absorption. (Click for more...) Monitoring the Phase Behavior of Supersaturated Solutions of Poorly Water-Soluble Drugs Using Fluorescence Techniques 10/12/2017 12:05:01 AM October 11, 2017 Phase transformations of poorly water-soluble drugs, in low concentration, supersaturated aqueous solutions are of considerable interest. Herein, fluorescence lifetime and steady-state fluorescence spectroscopy were employed to investigate the fluorescence properties of the autofluorescent compound, felodipine (a 1,4-dihydropyridine calcium channel blocker), when present as free drug in solution, drug-rich aggregates and crystals. Measurements were also performed in the absence and presence of liver microsomes. (Click for more...) Modeling and Prediction of Drug Dispersability in Polyvinylpyrrolidone-Vinyl Acetate Copolymer using a Molecular Descriptor 10/12/2017 12:05:01 AM October 11, 2017 The expansion of a novel in silico model for the prediction of the dispersability of 18 model compounds with polyvinylpyrrolidone-vinyl acetate copolymer (PVPva) is described. The molecular descriptor R3m (atomic mass weighted 3rd order autocorrelation index) is shown to be predictive of the formation of amorphous solid dispersions at two drug loadings (15% and 75% w/w) using two preparation methods (melt-quenching and solvent evaporation using a rotary evaporator). (Click for more...) Community Pharmacist Collaboration with a Patient Centered Medical Home: Establishment of a Patient-Centered Medical Neighborhood and Payment Model 10/12/2017 12:05:01 AM October 11, 2017 To determine the feasibility of a partnership between a community pharmacy and a PCMH by measuring the impact on office and patient-level clinical outcomes. (Click for more...) In Situ Monitoring and Modeling of the Solution-Mediated Polymorphic Transformation of Rifampicin: From Form II to Form I 10/12/2017 12:05:01 AM October 11, 2017 In this paper, the solution-mediated polymorphic transformation of rifampicin was investigated and simulated in three solvents at 30 °C. The solid state form I and form II of rifampicin was characterized by powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), Raman spectroscopy and fourier transform infrared spectroscopy (FTIR). To explore the relative stability, solubility data of form I and form II of rifampicin in butan-1-ol were determined using a dynamical method. (Click for more...) Discontinuing inappropriate medication use in nursing home residents 10/11/2017 9:00:01 AM October 11, 2017 A multi-site Dutch study implemented and evaluated an intervention targeting inappropriate prescribing in the nursing home setting. The research was carried out in 59 long-term care wards, with 426 patient–participants in all. A Multidisciplinary Multistep Medication Review (3MR)—involving critical appraisal of prescribed drugs, a look at the patient's medical history, and dialogue between physician and pharmacists, among other components—was performed for 233 patients in 33 wards. (Click for more...) Express Scripts to buy medical-benefits manager eviCore for $3.6 billion 10/11/2017 9:00:01 AM October 11, 2017 Express Scripts Holding has agreed to buy eviCore Healthcore, a private medical benefits manager, for $3.6 billion. The Bluffton, SC-based company, which was founded in 1994, will operate as a standalone business unit of Express Scripts. The deal is expected to close by year-end. St. Louis-based Express Scripts is acquiring eviCore from investors TA Associates, Ridgemont Equity Partners, and General Atlantic. (Click for more...) Puerto Rico's health care is in dire condition, 3 weeks after Maria 10/11/2017 9:00:01 AM October 11, 2017 Nearly 3 weeks after Hurricane Maria landed in Puerto Rico, hospitals are running low on medicine and high on patients, as they take in the infirm from medical centers where generators failed. The federal government has sent 10 Disaster Medical Assistance Teams of civilian doctors, nurses, paramedics and others to the island. Four mobile hospitals have been set up in hospital parking lots, and the Comfort, a medical treatment ship, is on the scene. A 44-bed hospital will soon open in badly wrecked Humacao, in the southeast. (Click for more...) FDA approves triamcinolone acetonide ER injectable suspension for OA knee pain 10/11/2017 9:00:01 AM October 11, 2017 FDA has approved triamcinolone acetonide extended-release injectable suspension (Zilretta—Flexion Therapeutics), the first extended-release, intra-articular injection for osteoarthritis knee pain. The nonopioid medicine employs Flexion's proprietary microsphere technology to provide pain relief for 12 weeks. The approval "comes at a time when our society is in urgent need of non-addictive therapies to help the millions of Americans who suffer from this condition," said Michael Clayman, MD, president and CEO of Flexion. (Click for more...) The latest on lice 10/11/2017 9:00:01 AM October 11, 2017 A clinical report on head lice issued by the American Academy of Pediatrics (AAP) in 2015 emphasized the need for careful diagnosis by trained observers. This indicates someone experienced should look at the child's head, looking for lice and not just for nits. Observers also should be aware of local patterns of resistance to anti-lice medications to determine the appropriate selection of OTC or prescription preparations. (Click for more...) Fauci: An HIV vaccine is essential for ending the HIV/AIDS pandemic 10/11/2017 9:00:01 AM October 11, 2017 Although there have been significant advances in the treatment and prevention of HIV, Anthony Fauci, MD—director of the National Institute of Allergy and Infectious Diseases—asserts that "development of an effective HIV vaccine will likely be necessary to achieve a durable end to the HIV pandemic." In a new commentary, Fauci notes that, in theory, effective implementation of existing HIV treatment and prevention methods worldwide could end the HIV pandemic. He points to the more than 30 highly effective anti-HIV drugs on the market as well as strategies such as pre-exposure prophylaxis. (Click for more...) Association of insulin pump therapy vs. insulin injection therapy with severe hypoglycemia, ketoacidosis, and glycemic control in T1D 10/11/2017 9:00:01 AM October 11, 2017 German researchers investigated whether rates of severe hypoglycemia and diabetic ketoacidosis were lower with insulin pump therapy compared with insulin injection therapy in children, adolescents, and young adults with type 1 diabetes. The population-based cohort study, conducted at 446 diabetes centers participating in the Diabetes Prospective Follow-up Initiative in Germany, Austria, and Luxembourg, involves patients with type 1 diabetes younger than age 20 years and with diabetes duration of more than 1 year. (Click for more...) Chicago moves closer to easing pharmacist workload 10/11/2017 9:00:01 AM October 11, 2017 The Chicago City Council Finance Committee on Tuesday approved a measure that would allow Chicago pharmacists to fill prescription orders for no more than 10 patients per hour, in an effort to reduce the workload of pharmacists. It also would require pharmacies to post a list in plain sight showing which pharmacists and technicians have worked shifts longer than 8 hours. The proposal's sponsor, Edward Burke, the committee's chairman, said he hoped to bring the plan up for a vote in the full City Council soon. (Click for more...) Compounded bioidentical hormone therapy: Does the regulatory double standard harm women? 10/11/2017 9:00:01 AM October 11, 2017 While use of menopausal hormone therapy products has trended downward in recent years, evidence suggests U.S. women increasingly are turning to compounded bioidentical hormone therapy (cBHT) to combat hot flashes and other symptoms. Pharmacists polled last year, for example, estimated that 26 million–33 million cBHT prescriptions are filled each year. The problem, warn Cynthia A. Stuenkel, MD, of the University of California, San Diego, and JoAnn E. (Click for more...) Tightly-controlled growing operations off to slow start for LA medical marijuana program 10/11/2017 9:00:01 AM October 11, 2017 Patients in Louisiana eligible for therapeutic marijuana under a 2015 law are still months away from having the drug in hand, with the state's medical marijuana program contending with regulations, tightly-controlled growing operations, and a slow selection process. Only the agricultural centers at Louisiana State University (LSU) and Southern University are permitted to grow the medical-grade marijuana, and the law allows a limited number of dispensing pharmacies. (Click for more...) Battle over drug prices shifts back to the states 10/11/2017 9:00:01 AM October 11, 2017 With little happening in the way of federal action to rein in the costs of prescription drugs, some states are taking matters into their own hands. "This is not an issue that’s going away, and it’s clear that patients are demanding action on this topic, and if they can’t succeed on the federal level, then they're going to the states," says Rachel Sachs, an associate law professor at the Washington University School of Law. On Monday, Gov. Jerry Brown of California signed drug pricing transparency legislation that supporters call the most robust law to date. (Click for more...) Trump names Eric Hargan as acting Health Secretary 10/11/2017 9:00:01 AM October 11, 2017 The White House announced Tuesday that President Trump has named Eric Hargan as acting secretary of HHS. Hargan, who was deputy secretary of the agency, previously served on Trump's transition team for HHS. The move comes after Tom Price resigned as HHS secretary in late September following outcry over his use of private charter planes for government transport. (Click for more...) Pharmacists in Puerto Rico help their communities after Hurricane Maria 10/10/2017 3:45:13 PM October 10, 2017 Despite Puerto Rico’s utter devastation after Hurricane Maria, pharmacists and pharmacy staff who live there are going above and beyond serving patients in their communities, said Justin Coyle, PharmD, senior director of pharmacy operations at Walgreens. “Team members have lost their homes and need basic needs like food, fuel, water, clothing, and shelter,” Coyle said. “Not only are they experiencing the storm as residents of Puerto Rico, they’re helping their community, and they’re helping their patients.” (Click for more...) Members spotlight: Mary Lynn McPherson, PharmD, MA, MDE, BCPS, CPE, and Alexandra McPherson, PharmD, MPH 10/10/2017 1:03:34 PM October 10, 2017 Mary Lynn McPherson (Click for more...) Continuous glucose monitoring for type 2 diabetes results in better glycemic control 10/10/2017 11:32:30 AM October 10, 2017 Compared with usual care, use of continuous glucose monitoring improved glycemic control in patients with poorly controlled type 2 diabetes who were receiving multiple daily injections of basal–bolus, according to results of a trial published in the Annals of Internal Medicine. (Click for more...) Breaking down barriers to antimicrobial stewardship in small hospitals 10/10/2017 11:17:29 AM October 10, 2017 Owing to their success in promoting patient safety at larger institutions, various national regulatory and accreditation agencies have mandated that all hospitals, regardless of size, implement antimicrobial stewardship programs (ASPs). (Click for more...) Californians will get more information on drug prices under new law 10/10/2017 9:00:02 AM October 10, 2017 Gov. Jerry Brown of California on Monday signed into law a measure to increase disclosure on prescription drug prices. The law will require drugmakers to provide notice to health plans and other purchasers 60 days in advance of a planned price hike if the increase exceeds certain thresholds. The law also requires require health plans to submit an annual report to the state that details the most frequently prescribed drugs, those that are most expensive and those that have been subject to the greatest year-to-year price increase. (Click for more...) Hospitals scramble to avert saline shortage in wake of Puerto Rico disaster 10/10/2017 9:00:02 AM October 10, 2017 Several prominent hospitals across the United States are responding to the disrupted production of widely used intravenous solutions caused by Hurricane Maria by searching for alternative supplies, changing the way they administer drugs, and devising backup plans to make the fluids themselves. The products affected are smaller-volume bags of sodium chloride, known as saline, and dextrose. Their manufacturer, Baxter International, reports that "multiple production days" were lost in the wake of the hurricane, and it has set up an allocation system for hospitals based on past purchases. (Click for more...) Baxter initiates voluntary nationwide recall of one shipment of intralipid 20% I.V. fat emulsion 10/10/2017 9:00:02 AM October 10, 2017 Baxter International has announced a voluntary recall of one shipment from a single lot of intralipid 20% fat emulsion, 100 mL. The product, which was distributed to hospitals and health care providers between August 11, 2017 and August 31, 2017, was exposed to subfreezing temperatures during transit to a distribution facility. If accidentally frozen, the emulsion droplets will increase in size, creating aggregates that can obstruct pulmonary circulation and lead to serious adverse health consequences. (Click for more...) FDA approves implantable device to treat moderate-to-severe central sleep apnea 10/10/2017 9:00:02 AM October 10, 2017 FDA approved on October 6 a new treatment option for patients with moderate-to-severe central sleep apnea. Central sleep apnea is when the brain fails to send signals to the diaphragm to breathe, which causes an individual to stop breathing during sleep for a period of 10 seconds or more before starting again. The implantable device (Remede System—Respicardia) stimulates a nerve located in the chest that is responsible for sending signals to the diaphragm to stimulate breathing. (Click for more...) Evaluation of a trainee-led project to reduce inappropriate PPI infusion in patients with UGIB 10/10/2017 9:00:02 AM October 10, 2017 In an effort to reduce overuse of proton pump inhibitor (PPI) infusions in patients with upper gastrointestinal bleeding (UGIB), a fellow- and resident-led intervention was launched in July 2015. Using the Culture, Oversight, Systems Change, Training framework, the study included electronic health record prompts for physicians to select an appropriate indication for PPI infusion orders, while pharmacists tracked monthly usage of PPI infusions. In addition, education was provided for internal medicine residents, hospitalists, and emergency medicine faculty and residents. (Click for more...) Amazon is headed for the prescription-drug market, analysts say 10/10/2017 9:00:02 AM October 10, 2017 Amazon.com Inc. is extremely likely to enter the business of selling prescription drugs by 2019, according to analysts at Leerink Partners. "It's a matter of when, not if," Leerink Partners analyst David Larsen said in a report to clients late Thursday. "We expect an announcement within the next 1-2 years." Leerink's calls with industry experts suggest that Amazon "is in active discussions" with mid-size PBMs and possibly larger player such as Prime Therapeutics, Larsen's colleague, Ana Gupte, wrote in a separate report Friday. (Click for more...) Bevacizumab for advanced cervical cancer: Final overall survival and adverse event analysis 10/10/2017 9:00:02 AM October 10, 2017 Bevacizumab won FDA approval for treatment of advanced cervical cancer based on preliminary trial evidence and now, 3 years later, final analysis of the study results has been completed. The Phase III investigation, which opened enrollment in early 2009, randomized participants into one of four arms: I.V. chemotherapy with cisplatin plus paclitaxel or topotecan plus paclitaxel, with or without I.V. bevacizumab. Patients received open-label treatment until disease progression, unacceptable toxic effects, patient withdrawal from the project, or complete response. (Click for more...) In wake of Harvey, Paramount Rx helps cover cost of tetanus vaccines at H-E-B stores 10/10/2017 9:00:02 AM October 10, 2017 Paramount Rx has teamed up with H-E-B to support the distribution of 2,500 tetanus vaccinations at no cost at H-E-B stores in areas hit hard by Hurricane Harvey. "Even as flood waters recede, leftover debris still pose a threat to those who have not received a tetanus booster in the last 10 years," said Ken Hammond, president of Paramount Rx. (Click for more...) Trump administration rolls back birth control mandate 10/10/2017 9:00:02 AM October 10, 2017 Hundreds of thousands of American women are at risk of losing access to free contraception, after the Trump administration repealed a federal mandate requiring employers to include it in their health care coverage. President Barack Obama's Affordable Care Act had made the protection available at no cost to more than 55 million users. Under new rules issued by HHS, however, any employer—including publicly traded companies—can decline to cover contraceptive services on religious or moral grounds, effective immediately. The timing of the new HHS rules coincide with a memo from U.S. (Click for more...) Vaccination challenges in confronting the resurgent threat from yellow fever 10/10/2017 9:00:02 AM October 10, 2017 Widespread distribution of Ae aegypti has renewed fears of yellow fever (YF) outbreaks among urban populations. Not only has the global stockpile of vaccine been depleted, a manufacturing debacle has dried up supplies of the only one (YF-VAX—Sanofi Pasteur) licensed for use in the United States. A new production facility due to start up in 2018 should ease the domestic bottleneck; but, in the meantime, FDA and CDC have allowed Sanofi Pasteur to import a similar vaccine, Stamaril, from France under the investigational new drug (IND) program. (Click for more...) Additional delivery of insulin ready for distribution in Puerto Rico 10/10/2017 9:00:02 AM October 10, 2017 Eli Lilly reported on October 5 that a new shipment of commercial medicines, including more than 36,000 vials and pens of insulin, had arrived in Puerto Rico. According to the company, the delivery includes 3,000 vials for humanitarian distribution and enough commercial insulin to help restock operational pharmacies. The company's first humanitarian shipment arrived just a few days after Hurricane Maria hit on September 20, and the total now includes 5,400 insulin pens and vials. (Click for more...) Update: Influenza activity--United States and worldwide 10/10/2017 9:00:02 AM October 10, 2017 In the United States and elsewhere, most documented influenza viruses during May 21–September 23, 2017, were similar to reference viruses representing the recommended components for the 2017–18 vaccine. Overall, activity was typical for the time of year, with low levels reported domestically. Most cases from late May through late June were tied to influenza B, with influenza A viruses becoming more prevalent starting in early July. (Click for more...) DHA and pGPMA Dual Modified pH Sensitive Polymeric Micelles for Target Treatment of Liver Cancer 10/10/2017 12:05:01 AM October 09, 2017 In clinical therapy, the poor prognosis of hepatocellular carcinoma (HCC) is mainly attributed to the failure of chemotherapeutical agents to accumulate in tumor as well as lack of potency of tumor penetration. In this work, we developed actively tumor-targeting micelles with pH-sensitive linker as a novel nanocarrier for HCC therapy. These micelles comprised of biodegradable PEG-pAsp polymers, in which PTX can be covalently conjugated to pAsp via an acid-labile acetal bond to form pH-responsive structures. (Click for more...) Schools of Medicine and Pharmacy alumni are WVU 2017 Homecoming Award recipients 10/4/2017 12:00:00 AM Three School of Medicine alumni and a School of Pharmacy graduate are being recognized by the WVU Alumni Association as 2017 Homecoming Award recipients. (Click for more...) Discussion leaders named for Post-Charlottesville Town Hall 9/19/2017 12:00:00 AM Seven volunteer discussion leaders will take part in the Health Sciences-WVU Medicine Town Hall this Wednesday (Sept. 20) at noon in the Patteson Auditorium at WVU. (Click for more...) WVU, WV attorney general expand eighth grade drug prevention program 9/12/2017 12:00:00 AM West Virginia Attorney General Patrick Morrisey and West Virginia University have partnered to expand a program aimed at sharing drug abuse prevention information with eighth grade students in West Virginia. The initiative, launched in March with the West Virginia University School of Nursing, now also involves West Virginia University's School of Pharmacy and two other universities. (Click for more...) Student and faculty international travel grants available 9/1/2017 12:00:00 AM In honor of the legacy of a long-time staff member in WVU's Global Health Program, the Global Engagement Office (GEO) at Health Sciences is pleased to announce that the application period for the Nancy Sanders Memorial Student Travel Grant and the Nancy Sanders Memorial Faculty Research Abroad Grant is now open. (Click for more...) WVU health care simulation week kicks off Sept. 12 8/30/2017 12:00:00 AM September 12 kicks off national Health Care Simulation Week, and the WV STEPS Center welcomes visitors to a series of events highlighting simulation education. (Click for more...) WVU in the News - Study aims to increase effectiveness of opioid addiction treatment 8/15/2017 12:00:00 AM A new study being conducted at WVU is aimed at increasing the effectiveness of addiction treatment. As many as 20 percent of people addicted to opioids will not respond to the standard treatment of suboxone. Genetic background is one of several factors WVU and the West Virginia Clinical and Translation Science Institute will study to provide better more patient-specific addiction treatment. Get the full story on WV Always. (Click for more...) West Virginia health research gets $55 million boost 8/1/2017 12:00:00 AM MORGANTOWN, W.Va. – Recommitting themselves to bring the benefits of research out of labs and hospitals and into the lives of West Virginia people and communities, a coalition of federal agencies, universities, hospitals and clinics will develop dozens of efforts over the next five years to battle addiction and cancer and reduce the impact of cardiovascular and neurological diseases. (Click for more...) Academy of Excellence in Teaching and Learning applications being accepted 7/20/2017 12:00:00 AM The WVU Health Sciences Faculty Development Program is now accepting applications, CVs and biographies for the 2017 Academy of Excellence in Teaching and Learning. (Click for more...) WVCTSI and WVU research aims to increase addiction treatment effectiveness 7/13/2017 12:00:00 AM MORGANTOWN, W.Va. – Up to 20 percent of people with opioid use disorder may not respond to standard treatment. A new study at West Virginia University seeks to understand why. (Click for more...) Madhavan named to Fulbright Specialist Roster 7/10/2017 12:00:00 AM The U.S. State Department has added S. Suresh Madhavan, Ph.D., of the WVU School of Pharmacy to Fulbright Specialist Roster for the next three years. (Click for more...) Leukemia Research Foundation supports cancer research at WVU 7/5/2017 12:00:00 AM The Leukemia Research Foundation has awarded $100,000 to Wei Du, M.D., Ph.D., of the West Virginia University Cancer Institute to investigate a method for increasing the effectiveness of stem cell transplantation. (Click for more...) Town Hall to focus on heart care and research Thursday, June 15 6/6/2017 12:00:00 AM Two WVU Medicine heart specialists will be the special guests at an open forum for Health Sciences and WVU Medicine faculty, staff, and students at noon on Thursday, June 15, in the Okey Patteson Auditorium in the Health Sciences Center. (Click for more...) Meet the Graduates: Lindsey Glotfelty 5/16/2017 12:00:00 AM When asked what she wanted people to know about her, Lindsey Glotfelty of Finzel, Maryland, stated it's not really what she wants people to know about her, but rather the messages she wants them to get. She has four lessons that she has learned in her life, and they are the principles by which she lives. (Click for more...) ASK WVU MEDICINE: Breast to Brain Cancer - Risks and Research 5/15/2017 12:00:00 AM Join Hannah Hazard-Jenkins, M.D. and Paul Lockman, Ph.D., doctors who are dedicating their efforts to research and treatment of breast cancer, at the next Ask WVU Medicine Community Conversation, Tuesday, May 23 at 6 p.m. in the WVU Health Sciences Center Fukushima Auditorium. (Click for more...) WVU School of Pharmacy's Suresh Madhavan recipient of Distinguished Pharmacy Alumni Award from Purdue University 5/9/2017 12:00:00 AM S. Suresh Madhavan, MBA, Ph.D., was the recipient of Purdue University College of Pharmacy's 2017 Distinguished Pharmacy Alumni Award. Dr. Madhavan was one of four Purdue alumni who received this award, which recognizes the recipient's outstanding achievements in professional and scientific endeavors. (Click for more...) Cancer researcher is first alum to lead WVU School of Pharmacy 4/26/2017 12:00:00 AM William (Bill) Petros, PharmD, FCCP, has been appointed to the position. (Click for more...) WVU recognizes Health Sciences staff and faculty 4/10/2017 12:00:00 AM West Virginia University honored 13 individuals and two teams at the Health Sciences Center for outstanding achievement on Wednesday, April 12 at 4 p.m. in the Pylons Lobby. (Click for more...) Frank Alderman, MD, to speak at WVU College of Business and Economics Distinguished Speaker Series 4/3/2017 12:00:00 AM Frank Alderman, MD, CEO of MedExpress and a graduate of the WVU Schools of Medicine and Pharmacy, will speak at the WVU College of Business and Economics's Distinguished Speaker Series on April 19 at 3:30 p.m. at the Morgantown Event Center. (Click for more...) WVU and WVCTSI fund two addiction projects 3/29/2017 12:00:00 AM MORGANTOWN, W.Va. – The West Virginia University (WVU) Addiction Task Force and West Virginia Clinical and Translational Science Institute (WVCTSI) have funded two new research projects to combat the opioid epidemic in the state. According to the Centers for Disease Control and Prevention, West Virginia continues to be devastated by this epidemic, having the highest rate of drug overdose deaths in the nation. (Click for more...) Vera Bradley Bingo Relay for Life fundraiser 3/28/2017 12:00:00 AM The West Virginia University School of Pharmacy Relay for Life Team and the Lambda Kappa Sigma student organization will be hosting a Vera Bradley Bingo at 1 p.m. on Sunday, April 2, in room 1909 at the WVU Health Sciences Center in Morgantown. Doors open at noon. (Click for more...) WVU health professions students provide information on fall risk prevention 3/24/2017 12:00:00 AM Students from the West Virginia University School of Pharmacy and School of Medicine Division of Physical Therapy visited Sundale Rehabilitation – Long Term Care on March 22 to discuss fall risk prevention. (Click for more...) FDA Outlines Conditions for Pharmacies to Repackage Drug Products 3/9/2017 7:00:00 PM A guidance issued by FDA on January 12 makes clear that the agency does not favor some long-standing habits of pharmacy personnel related to the repackaging of drug products. (Click for more...) Maine Pharmacists Eye Legislation to End Drug Plans' Retroactive Fees 3/9/2017 7:00:00 PM Direct and indirect remuneration (DIR) fees are a "dragon" that pharmacists in Maine are trying to slay, says Felicity Homsted, chief pharmacy officer for Penobscot Community Health Care (PCHC) in Bangor and president of the Maine Society of Health-System Pharmacists (MSHP). (Click for more...) Alabama Pharmacists Push for State Collaborative Therapy Law 3/9/2017 7:00:00 PM The February 7 start of Alabama's 2017 legislative session is a fresh opportunity for the state to codify collaborative drug therapy management (CDTM) as part of pharmacy practice. (Click for more...) HSC Interprofessional Education Week celebration is March 27-31 3/6/2017 12:00:00 AM Join us for the inaugural HSC Interprofessional Education Week celebration (Click for more...) New pharmacy scholarship honors longtime West Virginia pharmacist 3/6/2017 12:00:00 AM The Jack H. Smith Family Pharmacy Scholarship was established not only to honor Suzanne Smith-Fox's father, but to assist a student who holds the same values as her father – generosity, community involvement, quality citizenship and an outstanding passion for receiving an education. Jack was a 1956 graduate from the West Virginia University School of Pharmacy, and the endowed scholarship also honors Jack's father (Suzanne's grandfather) who was a pharmacist in Parkersburg, West Virginia. (Click for more...) Abuse Potential of Noncontrolled Drugs Often Overlooked, Official Says 2/26/2017 7:00:00 PM To get a real handle on drug abuse, clinicians need to look beyond opioids and consider the abuse potential of noncontrolled drugs, says Michael Cohen, operations officer for the investigations branch of the Department of Health and Human Services (HHS) Office of Inspector General (OIG) in Washington, D.C. (Click for more...) Updated Research Rule Aims for Friendlier Consent Process 2/26/2017 7:00:00 PM It's not just full-time researchers who need to grapple with the recently revised Common Rule, a federal regulation that underpins U.S. research involving human subjects. (Click for more...) Pharmacists Turn Naloxone Training Programs into Video for Broad Audience 2/26/2017 7:00:00 PM A pharmacy project to train emergency medical services (EMS) and law enforcement personnel in how to administer naloxone in cases of opioid overdose has grown into an educational effort that features a video aimed at any potential responder. (Click for more...) Family Focus Helps Pharmacist Improve Diabetes Care for Native Americans 2/12/2017 7:00:00 PM When Cherith Smith started work about a decade ago as a pharmacist at the Missoula Urban Indian Health Center in Montana, she saw a common thread of hopelessness in people with diabetes who visited the center. (Click for more...) VA Project Expands Clinical Pharmacy Services to Rural Veterans 2/12/2017 7:00:00 PM A major project at the Department of Veterans Affairs (VA) to position pharmacists as healthcare providers in rural settings is poised to generate new data on how pharmacists improve patient care. (Click for more...) Proposed Legislation, CMS Guidance Portend Advancements for Pharmacists 2/12/2017 7:00:00 PM Federal efforts to advance pharmacists' role in healthcare got off to a fast start in January with developments including the following: (Click for more...) Deflazacort Approved for Duchenne Muscular Dystrophy 2/9/2017 7:00:00 PM FDA and Marathon Pharmaceuticals LLC on February 9 announced the approval of deflazacort oral tablets and oral suspension for the treatment of Duchenne muscular dystrophy in patients 5 years of age or older. (Click for more...) WVU School of Pharmacy receives reaccreditation 2/9/2017 12:00:00 AM The West Virginia University School of Pharmacy's Doctor of Pharmacy (Pharm.D.) professional program recently received continued accreditation by the Accreditation Council for Pharmacy Education (ACPE). The accreditation is valid until 2025—a full eight years, which is the maximum length of time for ACPE's accreditation. (Click for more...) Baugh named director of interprofessional education for health sciences 12/19/2016 12:00:00 AM Gina M. Baugh, Pharm.D., associate professor and director of Introductory Pharmacy Practice Experiences at the West Virginia University School of Pharmacy, has been named director of interprofessional education for the WVU Health Sciences Center. (Click for more...) DEA registration renewal process changing 12/19/2016 12:00:00 AM As of January 1, 2017, those with an expired DEA registration will need to fully reapply; the DEA will no longer allow a grace period for expired registrants. (Click for more...) WVU Pharmacy students educate youth about substance and prescription drug abuse 10/31/2016 12:00:00 AM Second-year students at the West Virginia University School of Pharmacy visited West Preston School on Thursday, Oct. 27, to discuss the dangers of substance and prescription drug abuse. (Click for more...) WVU student pharmacists offer health screenings at Bridge Day 10/14/2016 12:00:00 AM MORGANTOWN, W.Va. — Students from the West Virginia University School of Pharmacy will be offering a variety of health screenings and information Saturday, Oct. 15, from 9 a.m. – 3 p.m. at Bridge Day at New River Gorge in Fayetteville, West Virginia. (Click for more...) WVU's food bank to open second location, The Rack II@HSC 10/6/2016 12:00:00 AM West Virginia University Health Sciences will soon open "The Rack II@HSC," WVU Health Sciences' Campus Food Bank, to assist with campus-wide efforts to address the growing population of homeless and/or hungry employees/students. (Click for more...) WVU Pharmacy student writes song to benefit disaster relief efforts 9/22/2016 12:00:00 AM MORGANTOWN, W.Va. — You never know from where a source of inspiration might come. (Click for more...) Griffith named WVU Medicine vice president of cancer services 9/21/2016 12:00:00 AM Niesha L. Griffith, a graduate of the West Virginia University School of Pharmacy, has returned to her alma mater as vice president of cancer services for WVU Medicine. She began her new role Sept. 13. (Click for more...) NIH awards WVU $1.8 million to widen health options for children 9/21/2016 12:00:00 AM Seriously ill children across West Virginia will have easier access to new medical treatments in their own communities, thanks to a four-year, $1.8 million grant awarded to West Virginia University today by the National Institutes of Health. (Click for more...) WVU to mark Morgantown Overdose Awareness Day with panel discussion 8/23/2016 12:00:00 AM Makalynn, a WVU student in a 12-step recovery program, is among the WVU and Morgantown representatives who will take part in a panel discussion at 7 p.m. Wednesday, Aug. 31, at the Mountainlair. (Click for more...) WVU Pharmacy students receive white coats 8/13/2016 12:00:00 AM When Deborah Pope of Martinsburg, West Virginia, was in middle school, she knew she wanted to be a health care professional when she grew up. A friend suggested becoming a pharmacist, and the more Pope researched the profession, she discovered it was the right career for her. (Click for more...) WV-INBRE program brings faculty and student researchers across the state to WVU and Marshall for research experience 8/10/2016 12:00:00 AM West Virginia University and Marshall University received a grant for approximately $16 million dollars in 2014 to be distributed over the course of five years from the National Institutes of Health (NIH) to support an Institutional Development Award (IDeA) Network of Biomedical Research Excellence (INBRE). (Click for more...) Change comes from within 8/8/2016 12:00:00 AM West Virginia University's responsibility as the state's Land Grant University is to use the power of knowledge and human connection to lift up people everywhere in our state. But as they say on airplanes, in an emergency you should put on your own oxygen mask first, before you attempt to help others. You can't be much help if you gasping for air. That's why WVU's vice president for health sciences has asked a group of leaders from across WVU Medicine and the Health Sciences Center – and outside our campus – to join the new Quality of Life Initiative. (Click for more...) WVU School of Pharmacy's Terry Schwinghammer recipient of national educator award 8/3/2016 12:00:00 AM Terry Schwinghammer, Pharm.D., was the recipient of the American Association of Colleges of Pharmacy (AACP) Robert K. Chalmers Distinguished Pharmacy Educator Award. (Click for more...) WVU offers free opioid use disorder training to West Virginia healthcare providers 7/20/2016 12:00:00 AM WVU is offering a free American Society of Addiction Medicine buprenorphine course, along with a one-day continuing education event, in two different locations in West Virginia – August 20 in Morgantown and September 17 in Charleston. (Click for more...) WVU Health Outcomes Ph.D. students receive accolades at international conference 6/17/2016 12:00:00 AM Graduate students in the West Virginia University School of Pharmacy Health Outcomes Research Ph.D. program were the recipients of several awards during the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) 21st Annual International Meeting. The meeting was held May 21–25 in Washington, D.C. (Click for more...) Two from WVU named BioWV leaders 5/23/2016 12:00:00 AM Two WVU researchers have been named to the leadership of BioWV, the Bioscience Association of West Virginia, a nonprofit organization that promotes the state's growing bioscience business community. (Click for more...) West Virginia University offers courses to reduce opioid use 5/3/2016 12:00:00 AM West Virginia University has added a new online course, "The Treatment of Pain and Addiction Utilizing Education and Proper Prescribing: The New Paradigm Continued." The course will provide West Virginia physicians, physician assistants, nurses, and dentists with continuing education credit, and also fulfill the state's requirement for training in avoiding diversion of prescriptions drugs into the illicit market. (Click for more...) Wigner Institute hosts AADE workshop 4/20/2016 12:00:00 AM The WVU School of Pharmacy Wigner Institute for Advanced Pharmacy Practice, Education, and Research sponsored an American Association of Diabetes Educators Workshop on April 18. Attendees included pharmacists, nurses, and dietitians from clinics, hospitals, pharmacies, and health departments from 40 counties throughout the state. (Click for more...) WVU BOG approves new degree programs, receives update on Beckley campus 4/19/2016 12:00:00 AM The WVU Board of Governors gave final approval to repurpose an existing School of Pharmacy Ph.D. track into its own independent doctoral program, which will offer a new doctor of philosophy degree in health services and outcomes research. (Click for more...) Outstanding Graduate Student and Mentor awards ceremony 4/13/2016 12:00:00 AM On April 8, 2016, the Office of Research and Graduate Education recognized the achievements and participation of our graduate students in the research, teaching and service missions of the Health Science Center. As part of this ceremony, awards were given to faculty who are outstanding mentors and to graduate students who are outstanding in their graduate programs. (Click for more...) Inspiring Students 4/6/2016 12:00:00 AM I had a lot of fun recording some video with students from each of the Health Sciences schools Tuesday for a back to school video in the fall. (Click for more...) WVU student pharmacists host Senior Olympics 4/1/2016 12:00:00 AM Students from the West Virginia University School of Pharmacy hosted a Senior Olympics for local seniors to stress the importance of physical fitness. (Click for more...) Going global for health education 1/14/2016 12:00:00 AM Beginning in January 2016, faculty and students of the West Virginia University School of Pharmacy will gain a new global opportunity for education and collaboration. (Click for more...) Gold and Blue celebration in Oman 1/13/2016 12:00:00 AM More than 110 newly-graduated health professionals – decked out in West Virginia University's gold-and-blue colors – received diplomas from Oman Medical College Sunday (Jan. 10) in an outdoor ceremony at the Intercontinental Muscat Hotel. (Click for more...) Pack the Rack success 1/13/2016 12:00:00 AM WVU Health Sciences and WVU Medicine faculty, students, and staff donated 944 food items to The Rack – the WVU student food bank – during the "Pack the Rack" holiday drive in November and December, according to Jacqueline Dooley, The Rack program director. (Click for more...) Dr. Clay Marsh meets with Oman health minister 1/11/2016 12:00:00 AM In a meeting Sunday with Oman's minister of health, WVU's vice president for health sciences discussed health challenges common to people and communities in Oman and West Virginia. (Click for more...) New Practitioner Mentor Program 7/16/2012 12:39:22 PM October 11, 2017 The purpose of the APhA New Practitioner Mentor Program is to provide student pharmacists the opportunity to interact with a new practitioner who can provide insight into the transition from student to...Only Member or Student have full access to this content. Log in to view full content. (Click for more...)
 
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